This paper investigates estimation and inference of a Spatial Arbitrage Pricing Theory (SAPT) model that integrates spatial interactions with multi-factor analysis, accommodating both observable and latent factors. Building on the classical mean-variance analysis, we introduce a class of Spatial Capital Asset Pricing Models (SCAPM) that account for spatial effects in high-dimensional assets, where we define {\it spatial rho} as a counterpart to market beta in CAPM. We then extend SCAPM to a gene...