A control theoretical approach to gene regulation raises quantitative constraints for dynamic homeostasis in stochastic gene expression

Cell phenotype dynamic homeostasis contrasts with the inherent randomness of intracellular reactions. Although feedback control of master regulatory genes (MRG) is a key strategy for maintaining gene network expression ranges limited, understanding the quantitative constraints and corresponding mechanisms enabling such a dynamic stability under noise remains elusive. Here we model MRG expression as a stochastic process and downstream genes as sensors which response conditionally induce MRG activ...