Chronic kidney disease (CKD) is a significant public health challenge, often progressing to end-stage renal disease (ESRD) if not detected and managed early. Early intervention, warranted by silent disease progression, can significantly reduce associated morbidity, mortality, and financial burden. In this study, we propose a novel approach to modeling CKD progression using a combination of machine learning techniques and classical statistical models. Building on the work of Liu et al. (2023), we...